IL-26: inducing inflammation

Carbon nanotubes provoke inflammation by inducing the pro-inflammatory genes IL-1β and IL-6.

Carbon nanotubes (CNTs) are largely produced and widely used because of their novel features, and the annual yield is expected to increase dramatically in the near future. Meanwhile, adverse health influences from exposure to CNTs are widely concerned, partially due to their asbestoid characteristics. In the current study, to assess the inflammatory responses and related mechanisms, we establis...

The role of the novel Th17 cytokine IL-26 in intestinal inflammation.

BACKGROUND AND AIMS Interleukin 26 (IL-26), a novel IL-10-like cytokine without a murine homologue, is expressed in T helper 1 (Th1) and Th17 cells. Currently, its function in human disease is completely unknown. The aim of this study was to analyse its role in intestinal inflammation. METHODS Expression studies were performed by reverse transcription-PCR (RT-PCR), quantitative PCR, western b...

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.

Hypoferremia is a common response to systemic infections or generalized inflammatory disorders. In mouse models, the development of hypoferremia during inflammation requires hepcidin, an iron regulatory peptide hormone produced in the liver, but the inflammatory signals that regulate hepcidin are largely unknown. Our studies in human liver cell cultures, mice, and human volunteers indicate that...

IL-26 Kick-Starts Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune disease that afflicts millions of people worldwide, wherein cells of the immune system attack tissues that seem otherwise healthy, causing pain and tissue damage. Usually the immune cells attack the joints, although other tissues may come under attack as well. What instigates this assault, and what governs its spread to previously unaffected tissues, i...

Pertussis Toxin by Inducing IL-6 Promotes